• BCR/ABL1 is the primary gene rearrangement associated with Chronic Myeloid Leukemia (CML), resulting from a translocation between chromosomes 9 and 22.

• This rearrangement creates a protein that drives cellular growth out of control and leads to overproduction of certain blood cells.

• FISH for BCR/ABL1 allows the translocation to be identified at diagnosis and monitored for disease progression or relapse.

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Sample Requirements:

• Bone Marrow

  • 2-5 mL in a sodium heparin (green top) tube for all tests.

  • 5 mL in a EDTA (purple top) is acceptable for FISH and molecular testing only

  • Minimum: 1 mL

• Storage:  Room temperature if being shipped within 24 hours.  Refrigerate if shipping will be delayed.

• Stability: Sample is optimum if received within 48 hours.

• Transportation:  Room temperature (do not freeze or fix)